What is causing my 5.4 to backfire and run rough

No codes? Backfiring is usually timing problems or some reason unburned fuel explodes in the combustion chamber during exhaust stroke. If the spark fails in one or more cylinders while engine is running it will backfire, you have a spark and/or timing issue

Hold on I was not paying attention..the cat glowing...running rich...o2 sensor or some other reason too much unburned fuel in it

Have replaced cats , plugs and coil packs. also fuel pump no results

If the cat is glowing red it sounds likes its stopped up, came apart on the inside.that would cause your truck to run bad cant get the exhaust out. replace the cat that is glowing red you will probaly find chunks fallin out when you remove it