Can I do a swap

If you swap over donor engines ECM you may have to disable VATS on your truck, but if the two engines are identical you may be able to keep your current ECM without any issues. Does seem a little pricey and a lot of work for a high-mileage engine swap tho.

Will it work thought is my question... I have 160k on mine

I don't know what motors you have in either vehicle, but if they are the same (ie 4.3) then I see no reason for the swap not to work. The common issue to deal with in engine swaps in newer vehicles is the engine computer, it needs to be flashed to a factory setting matching the new engine, taking into consideration gear ratios or tranny gears and rear end, engines induction system, etc. IF the donor engine has major redesigns, or tranny/rear end are geared much differently, then the old computer won't work with it well, may result in running rough. IF the donor engine were IDENTICAL in every way, then the old computer would work with it. Of course the engine computer also holds other programmed variables such as mileage, VIN info, and anti-theft system, which is where swapping computers means having to reflash and program for anti-theft. If I'm not mistaken, you have a VATs era truck, which I believe can be disabled as opposed to the expense of reprogramming. Go join a GMC Jimmy or S-10/Blazer forum where members post guidelines on such swaps, they'll have way more information on the subject and can walk you though it. This forum is very limited in what type of responses we can give and not suited for detailed instructions.

hello i had a 99 chevy runing but body was really rusting out bad i found a 01 blazer on line suppose to be runing but i found out it had a bad engine so i had the engine pulled from the 01 and i paid some 1 to swamp engine and the shop telln me the 99 wont run in the 01 blazer can some 1 help me please