94 F250 won't start

I have a 94 F250 that would not start....After going through the ignition system  with a
test light and spark plug ignition wire tester (plugs/wires/coil) I had a bad coil. I
replaced it and started right up. As a maintenance precaution I replaced the fender wall
mounted control module as well.

Ran flawlessly for 2 months...I parked it and went on vacation for two weeks...now it
won't start.

I have spark, but no fuel. I can hear both fuel pumps engage. At first I would hear them
run about 2 seconds and come to pressure.....sometimes if it sat a day or three it
would fire right up and run fine while parked. (manual trans w/4x4) But the next day it
would again fail to start.

After this I noticed a distinctive change in how the fuel pumps sound...one has a very
high pitch whine and doesn't stop giving the idea it has reached pressure.(front tank,
with low fuel amount)
The rear one whines also but with a lower pitch and again..just continues to run not
indicating it is at pressure.

I replaced the frame mounted fuel filter and afterwards the fuel pumps acted
normal(initial energize and the 2 secs indicating to me they were at pressure?) it fired
right up...drove it around town and took it to the highway for a test run for 15mins. It ran
fine and flawless. Shut it off and restarted...great.

Today...3 days later, it again just cranks and cranks, but the fuel pumps now both
make the high pitch whine and do not stop indication they are at pressure.

I now have a check engine light which it has never had?

Any idea what my issue is?

3 days later.....